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Osteoporosis Osteoporosis Basics

Hidden Causes of Osteoporosis


Author:

Martin Nydick, MD, FACP

New York Hospital--Cornell Medical Center

Medically Reviewed On: May 14, 2001

There are 10 million people living with osteoporosis in the United States today, and 18 million more have low bone mass, putting them at risk for the disease. Many of us are aware of the connection between low calcium intake and osteoporosis. But there are a number of secondary causes of the disease that are not as well known. Below, endocrinologist Dr. Martin Nydick, of the New York Presbyterian Hospital, discusses some of these secondary causes.

Q: What are the major risk factors for osteoporosis?
The loss of estrogen at menopause is the most significant factor. Family history of osteoporosis and certain lifestyle habits, such as alcohol and cigarette smoking, are also relatively common risk factors.

Q: What are some of the secondary causes of the disease?
Certain medications and medical conditions can cause osteoporosis. Corticosteroids, which are commonly used for rheumatoid arthritis or asthma, and thyroid hormone medication can put people at risk for osteoporosis. Hyperparathyroidism, where the parathyroid glands in the neck are overactive, can also put people at risk. Certain people have difficulty absorbing calcium and vitamin D into their systems, and this is a risk factor for osteoporosis as well. For instance, lactase deficiency is a very common condition that results in difficulty with the absorption of lactose in milk. Some of these people with lactase deficiency may actually have a low-grade form of sprue, which is an intestinal inflammation that can cause malabsorption of various nutrients including calcium and vitamin D.

Q: So osteoporosis is not just a disease caused by estrogen loss?
No. It is important to always look for a secondary cause of this disease. It should never be simply assumed that osteoporosis is a direct result of menopause and estrogen loss.

Q: Certain antacids, which are generally assumed to be calcium-rich, can actually cause calcium depletion. Can you explain this?
Some antacids contain aluminum, and aluminum is actually a poison to the bones. However, this risk factor is probably not significant for most people, unless they are taking very large amounts of aluminum-containing antacids.

Q: Are secondary causes of osteoporosis more common in certain groups of people?
The most common cause of osteoporosis is estrogen deficiency, and as this deficiency is not a problem in men, we find that disease in men is most commonly attributed to secondary causes. Approximately 50 percent of the men who have osteoporosis tend to have a secondary cause.

Q: Are men often resistant to an osteoporosis diagnosis because it is a disease more prevalent in older women?
Absolutely. The other day, I had a female patient with osteoporosis who came in with her husband. He was small and bent over, and I recommended that he get a bone density test, which is the most reliable diagnostic tool for this disease, and he refused.

Q: So it never hurts to talk to your doctor about your risk for this disease, no matter what your gender or your age?
That's right.

Conclusion
Osteoporosis can be a devastating condition. Over 1.5 million osteoporosis-related fractures occur each year, usually in the hip or the spine, and primarily in older women. But osteoporosis is also one of the most preventable diseases. Most fractures could be avoided or prevented with density testing, preventative measures, and appropriate medical treatment.

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