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Infectious Diseases Current Topics in Infectious Diseases

Preparing for Next Year's West Nile Virus


Medically Reviewed On: November 27, 2002

By Erica Heilman

Mosquito season is over, the danger of West Nile virus (WNV) infection has passed, and now the Centers for Disease Control and Prevention (CDC), together with state health departments must prepare for next year's outbreak. This year introduced the first cases of blood transfusion-related virus transmission, which has spurred efforts to develop a WNV screening test for the nation's blood supply. Officials from the Food and Drug Administration (FDA) and CDC have agreed to work together to ensure that a screening system is in place by the time next year's WNV season peaks, but this could prove to be a difficult time frame.

Below, Dr. Lyle Petersen, the Deputy Director for Science with the Division of Vector-Borne Infectious Diseases at the CDC, discusses pressing issues for next year's West Nile outbreak, and offers practical advice and predictions about a highly unpredictable virus.

There is currently no test that screens for West Nile virus in donated blood. How great is the risk of infection for people who receive donor blood or organs?
You're right that there's no test that is suitable for screening the entire blood supply. A number of people acquired West Nile from blood transfusion and these transfusions were from donors who donated during the summer, when West Nile virus was active. The risk is going down day-by-day as the number of available units of blood that were collected during the peak time period of risk are being used up.

If somebody needs a blood transfusion or an organ transplant, and they're concerned about the virus, they should discuss it with their doctor. However, I'd like to emphasize that if you need a blood transfusion or transplant, its benefits far outweigh the risk of West Nile virus.

Can you discuss current efforts to develop a screening test?
There are a number of companies that are actively trying to develop tests suitable for screening of the U.S. blood supply. The FDA has expressed a desire to have a blood-screening test available and ready to go by the next transmission season, which is going to start somewhere around June. Whether a screening test can be developed and implemented before that time is a big question right now. Even if a blood screening test were available today, implementing it would still require a huge amount of work. Blood centers need equipment, they have to have people to do it, they have to have a computer system developed to get the test results. It's a huge undertaking.

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